Full text of "USPTO Patents Application 09589288"

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wo 02/02641 



PCT/USOl/19110 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 251 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<:400> 251 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu Gly Phe Tyr 
100 105 110 



Pro Val Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp' Val 
165 170 175 



wo 02/02641 



PCT/USOl/19110 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
19S 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 252 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 252 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu His Tyr His 
100 105 110 



Thr His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 150 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
130 ' 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 253 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 253 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly tie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr PHe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Asp Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190- 



Gly Thr Ser Arg Arg Ala Ala Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 254 
<211> 251 
<212> PRT 

<213> Homo sapiens 



<400> 254 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Asn Lys Pro Gly Ala 



Ser Val Lys Gly Ser Cys Lys Ala Tyr Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



301 



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PCT/USOl/19110 



Gly Trp He Asn Asp His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Tyr Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val He His Phe Leu 
100 105 110 



Pro Leu Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 ,200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 255 
<211> 251 
<212> PRT 

<213> Homo sapiens 



302 



wo 02/02641 



PCT/USOl/19110 



<400> 255 

Gin Val Gin Leu Val Gin Ser Ala Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leii Glu Trp Val 



Gly Trp He Ser Gly His Gly Asp Ser Thr Lys Tyr' Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val He Pro Phe Leu 
100 105 110 



Pro Leu Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 . 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu- Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
1S5 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



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PCT/USOl/19110 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 256 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 256 

Gin Val Gin Leu Val Gin Ser'Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Ala Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Tzp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 257 

<211> 251 

<212> PRT 

<213> Homo sapie: 



<400> 257 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val. Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



305 



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PCT/USOl/19110 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
1S5 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Asn Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 258 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 258 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Glu Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 



wo 02/02641 



PCT/USOl/19110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
155 170 175 



Ala Trp Tyr Gin Gin Arg Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
IBO 135 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 259 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 259 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr'Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Met His Tyr Leu 
100. 105 110 



Pro Val Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 leo 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 • 170 175 



Gly Thr Ser Arg Arg Ala, Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala ■ Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 260 
<211> 251 
<212> PRT 
<;213> Homo sapiens 

<400> 260 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



308 



wo 02/02641 



PCT/USOl/19110 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu Glu Phe Phe 
100 105 110 



Ser His Trp Gly Gin Gly Tiir Met Val Thr Val Ser Ser Gly Gly Gly 
lis 120 125 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



309 



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PCT/USOl/19110 



<210> 261 
<211> 244 
<212> PRT 

<213> Homo sapiens 
<400> 261 

Gin Val Gin Leu Ala Glu Ser Gly Gly Gly Leu Val Gin Pro Gly ft.rg 



Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Asp Asp Tyr 



Ala Met His Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Asp Trp Val 



Ser Ala lie Thr Trp Asn Ser Gly His lie Asp Tyr Ala Asp Ser Val 



Glu Gly Arg Phe Ala Val Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 



Leu Gin Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 



Thr Lys Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asn Trp Gly 
100 105 110 



Gin Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
115 120 125 



Gly Gly Ser Gly Gly Gly Gly Ser Asp He Gin Met Thr Gin Ser Pro 
130 135 140 



Ser Ser Leu Ser Ala Ser He Gly Asp Arg Val Thr He Thr Cys Arg 
145 150 155 ISO 



Ala Ser Gin Gly He Arg Asn Tyr Leu Ala Trp Tyr Gin Gin Lys Pro 
165 170 ■ 175 



Gly Lys Ala Pro Lys Leu Leu He Tyr Ala Ala Ser Thr Leu Gin Se; 
180 185 190 



Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
195 200 205 



wo 02/02641 



PCT/USOl/19110 



Leu Thr He Ser Ser Leu Gin Pro Glu Asp Val Ala Thr Tyr Tyr Cys 
210 215 220 



Gin Lys Tyr Asn Ser Ala Pro Tyr Ala Phe Gly Gin Gly Thr Lys Val 
225 230 235 240 



Glu He Lys Arg 



<210> 262 

<211> 251 

<212> PRT 

<213> Homo sapiei 



<400> 2S2 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu -Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val He His Tyr Leu 
100 105 110 



Val Thr Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



311 



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PCT/USOl/19110 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 . 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



<210> 263 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 263 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu Pro Tyr Tyr 
100 105 110 



Thr Leu Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 



wo 02/02641 



PCT/USOl/19110 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 .140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 • 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
130 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 254 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 264 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val • Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 



313 



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PCT/USOl/19110 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu His Tyr Tyr 
100 105 110 



Pro lie Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro, Arg Leu Leu Met Tyr 
180 ' 185 190 



Gly Thr Ser- Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



<210> 265 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 265 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 . 



wo 02/02641 



PCT/USOl/19110 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu Trp Phe Tyr 
100 105 110 



Pro Leu Irp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr' Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 256 
<211> 251 



wo 02/02641 



PCT/USOl/19110 



<212> PRT 

<213> Homo sapiens 

<400> 266 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Ala Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 • 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



wo 02/02641 



PCT/USOl/19110 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Gly Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 267 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 267 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg, Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



wo 02/02641 



PCT/USOl/19110 



Ala Trp Tyr Arg Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



<210> 268 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 268 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Met Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 



318 



wo 02/02641 



PCT/USOl/19110 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp lie 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 269 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 259 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



319 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu His Tyr Tyr 
100 105 110 



Thr His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 270 

<211> 251 

<212> PRT 

<213> Homo sapiens 



<400> 270 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 



wo 02/02641 



PCT/USOl/19110 



Gly Trp Val Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Qlu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu His Tyr Tyr 
100 105 110 



Ala Tyr Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 • 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 271 
<211> 251 
<212> PRT 
<213> Homo sapiens 



<400> 271 



wo 02/02641 



PCT/USOl/19110 



Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Arg Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Sar 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



322 



wo 02/02641 



PCT/USOl/19110 



Pfae Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 272 
<211> 251 
'<212> PRT 
<213> Homo sapiens 

<4Q0> 272 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val lie His Phe Tyr 
100 105 110 



Ser Leu Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Gly Thr' Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



<210> 273 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 273 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Gly Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gly Phe Phe 
100 105 110 



Pro His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 



324 



wo 02/02641 



PCT/USOl/19110 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 274 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 274 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Met Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp. Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



325 



wo 02/02641 



PCT/USOl/19110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu . Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



<210> 275 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 275 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 SO 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala Met Thr Ala Asp Thr Ser Thr .Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 ■ 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 . 



<210> 276 

<211> 251 

<212> PRT 

<213> Homo sapiens 



<400> 276 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



327 



wo 02/02641 



PCT/USOl/19110 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys- Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 135 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



wo 02/02641 



PCT/USOl/19110 



<210> 277 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 277 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp He Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala. Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



> His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin , Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser 'Gly Ser 
195 200 205 



wo 02/02641 



PCT/USOl/19110 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 278 
<211> 251 
<212> PRT 
<213> Horao sapiens 



<400> 278 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 ■ 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Gly Gin Ser Val Thr Arg Gly Trp Val 



330 



wo 02/02641 



PCT/USOl/19110 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 .195 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 ■ 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 279 
<211> 251 
<212> PRT 
<213> Homo sapiens 



<400> 279 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Ala His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
. 115 120 125 



331 



wo 02/02641 



PCT/USOl/19110 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Asp Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 280 
<211> 244 
<212> PRT 
<213> Homo sapiens 

<400> 280 

Gin Val Gin Leu Val Glu Ser Gly Gly Gly Leu Val Gin Pro Gly Arg 



Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 



Ala Met His Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Asp Trp Val 



Ser Ala lie Thr Trp Asn Ser Gly His lie Asp Tyr Ala Asp Ser Val 



Glu Gly Arg Phe Ala Val Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 



332 



wo 02/02641 



PCT/USOl/19110 



Leu Gin Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 



Thr Lys Ala Ser Tyr Leu Ser Thr Ser Ser Ser Leu Asp Asn Trp Gly 
100 • 105 110 



Gin Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
115 120 125 



Gly Gly Ser Gly Gly Gly Gly Ser Asp He Gin Met Thr Gin Ser Pro 
130 135 140 



Ser Ser Leu Ser Ala Ser He Gly Asp Arg Val Thr He Thr Cys Arg 
145 150 155 150 



Ala Ser Gin Gly He Arg Asn Tyr Leu Ala Trp Tyr Gin Gin Lys Pro 
165 170 . 175 



Gly Lys Ala Pro Lys Leu Leu He Tyr Ala Ala Ser Thr Leu Gin Ser 
180 185 190 



Gly Val Pro Ser Arg.Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
195 200 205 



heu Thr He Ser Ser Leu Gin Pro Glu Asp Val Ala Ala Tyr Tyr Cys 
210 215 220 



Gin Lys Tyr Asn Ser Ala Pro Tyr Ala Phe Gly Gin Gly Thr Lys Val 
225 230 235 240 



Glu He Lys Arg 



<210> 281 

<211> 251 

<212> PRT • 

<213> Homo sapiens 



<400> 281 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



wo 02/02641 



PCT/USOl/19110 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys- Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Lys 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 282 
<211> 251 
<212> PRT 



wo 02/02641 



PCT/USOl/19110 



<213> Homo sapiens 
<400> 282 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 .55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 '75 80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Ser Arg Leu Leu Met Tyr 
130 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Lys Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



335 



wo 02/02641 



PCT/USOl/19110 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Qly Gin Gly Thr Arg Leu Glu lie Lys Arg 
' 245 250 



<210> 283 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 233 

Gin Val Glh Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



1.1a Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu Asp Phe Tyr 
100 105 110 



Ser Val Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu' Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 



wo 02/02641 



PCT/USOl/19110 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 284 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 284 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly 1 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro He Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 135 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Gly 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



I Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 285 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 285 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Pro Phe Tyr Asp Thr Leu 'Hit Ser Tyr Val Leu Tyr Tyr Tyr 
100 105 110 



Ala Phe Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170' 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
ISO 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro' Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Gin Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 28S 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 28S 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



wo 02/02641 



PCT/USOl/19110 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



I His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Ala Asp Arg Phe Ser Asp Ser 
195 200 • 205 . 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 287 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 287 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



340 



wo 02/02641 



PCT/USOl/19110 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60, 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Phe Phe Tyr 
100 105 110 



Pro Phe Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 150 



Ala Thr Leu Ser Cys Arg Ala Gly Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 238 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 238 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Wet Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 HO' 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro, Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Asp Val Pro Asp Arg Phe Ser Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 289 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 289 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Ala Lys Lys -Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



wo 02/02641 



PCT/USOl/19110 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 290 
<211> 251 
<212> PRT 
<213> Homo sapiens 



<400> 290 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Phe Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val- Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
1S5 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 291 
<211> 251 
<212> PRT 
<213> Homo sapiens 



<400> 291 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
55 70 75 80 

lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 ■ 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
1S5 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Leu Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<:210> 292 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 292 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



346 



wo 02/02641 



PCT/USOl/19110 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Val Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 SO 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
S5 70 75 80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



i His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



wo 02/02641 



PCT/USOl/19110 



<210> 293 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 293 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp Val Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val lie Pro Phe Leu 
100 105 110 



Thr His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg. 
145 150 , 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 



wo 02/02641 



PCT/USOl/19110 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 294 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 294 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser' Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu Glu Phe Phe 
100 105 110 



Pro Asp Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 - 170 175 



wo 02/02641 



PCT/USOl/19110 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
X80 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu ' 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 295 

<211> 251 

<212> PRT 

<213> Homo sapiens 



<400> 295 

Gin Val Gin Leu Ala Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
20 25 30 

Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg- Pro Phe Tyr Asp Thr Leu Thr- Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 ■ 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu- Glu He Lys Arg 
245 250 



<210> 296 
. <211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 296 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Tzp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 80 



wo 02/02641 



PCT/USOl/19110 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp Arg Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
lis 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 , 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Sar Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 297 
<211> 251 
<:212> PRT 
<213> Homo sapii 



<400> 297 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
352 



wo 02/02641 



PCT/USOl/19110 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Glu Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu' Arg 
145 ISO 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Va-l 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 ' 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 298 
<211> 251 
<212> PRT 

<213> Homo sapiens 



wo 02/02641 



PCT/USOl/19110 



<400> 298 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 ' 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 80 

lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 . 125 



Gly Ser 'Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser He Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
ISO 185 ■ 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 



wo 02/02641 



PCT/USOl/19110 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 299 

<211> 251 

<212> PRT 

<212> Homo sapiens 



<400> 299 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu. Glu Trp Val 
35 40 45 

Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 ■ 75 . 80 

lie Glu Leu Arg Ser Leu Lys Ser Gly Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 12 0 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 - 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 ■ 250 



<210> 300 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 300 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 . 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Thr Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
1S5 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro 'Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Ala Arg Leu Glu He Lys Arg 
245 250 



<210> 301 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 301 

Gin He Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 80 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly. Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Glh Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 . 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 302 
<211> 251 
<212> PRT 
c;213> Homo sapiens 

<400> 302 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



358 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 . 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140. 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp He 
165 170 175 



Ala Trp Tyr Gin Gin Lys P.ro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 , 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 303 
<211> 251 
<212> PRT 
<213> Homo sapiens 



<400> 303 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



wo 02/02641 



PCT/USOl/19110 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala ^Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 1S5 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Lys Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 



wo 02/02641 



PCT/USOl/19110 



<210> 304 
<211? 251 
<212> PRT 
<213> Homo sapiens 

<400> 304 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ph.e Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Leu His Tyr Tyr 
100 105 110 



Ala His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 ■ 205 



wo 02/02641 



PCT/USOl/19110 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 305 
<211> 251 
<212> PRT 
<213> Homo sapii 



<400> 305 

His Val Gin Leu Val Leu Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
' 35 40 45 

Gly Trp He Ser Gly Arg Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55- 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly. Glu Arg 
145 150 155 160 



wo 02/02641 



PCT/USOl/19110 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
1S5 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



.Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 30S 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 306 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 SO 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Val Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



I His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 307 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 307 

Gin Val, Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



wo 02/02641 



PCT/USOl/19110 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr Val Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 308 
<211> 251 
<212> PRT 
<213> Homo sapiens 

<400> 308 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Aan His 
20 25 30 



wo 02/02641 



PCT/USOl/19110 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Ser Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



wo 02/02641 



PCT/USOl/19110 



<211> 251 
<212> PRT 

<213> Homo sapiens 
=:400> 309 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 ^ 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Glu Thr 
130 135 , 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165- 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 ■ 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 2 00 2 05 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



3S7 



wo 02/02641 



PCT/USOl/19110 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 

Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 310 
<211> 251 
<212> PRT 

<213> Homo sapiens 

<400> 310 
Gin 



Gly lie 



Gly 



Val Gin Leu Val Gin Ala Gly Val Glu Val Lys Lys Pro Gly Ala 
5 10 15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Ser Trp Val Arg Gin Ala Pro Gly Gin Glu Leu Glu Trp Val 
35 40 45 

Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 "80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 

Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 

Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 

Thr Leu Thr Gin Ser Pro Asp 'Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 150 

Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
1S5 170 175 



368 



wo 02/02641 



PCT/USOl/19110 



Ala Trp Tyr Gin Gin Arg Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185- 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 311 
<211> 251 
<212> PRT 

<213> Homo sapiens 



<400> 311 

Gin Val Gin Leu Val Gin Ala Ala Val Glu Val Lys Lys Pro Glu Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 

20 25 30 

Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 

35 ' 40 45 

Gly Trp He Ser Asp His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 

50 55 60 

Gin Gly Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 

55 70 75 80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Asp Ala Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 ' 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 , 150 • 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 , 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Ser Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 312 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 312 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly He -Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
S5 70 75 BO 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
370 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Glri Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 . 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 313 
<211>-251 
<212> PRT 

<213> Homo sapiens 
<400> 313 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



wo 02/02641 



PCT/USOl/19110 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser. Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 ■ 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100; 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 314 

<211> 251 

<212> PRT 

<213> Homo sapiens 



wo 02/02641 



PCT/USOl/19110 



<400> 314 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55- SO 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65 70 75 80 

He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Sly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro. Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Ala Tyr Arg Phe Ser Ala Ser 
195 200 205 



Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ser Thr Ser Pro Arg Thr 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 ■ 250 



<210> 315 
<211> 251 
<212> PRT 
<213> Homo sapiens 



<400> 315 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser, Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



• Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 ■ 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170- 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Thr Arg Leu Val Met Tyr 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 

195 ■ 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 316 
<211> 251 
<212> PRT 

<213> Homo sapiens 



<400> 316 

. Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 
20 25 30 

Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 
35 40 45 ■ 

Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 ' 55 60 

Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Sar Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Leu Thr Gin Ser Thr Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 17.0 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Ser Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Tyr Ala Val Tyr Tyr -Cys Gin Gin Tyr Asp Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 317 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<400> 317 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 



wo 02/02641 



PCT/USOl/19110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Se: 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Arg Leu Glu Pro Glu 
210 215 220 



^ Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Gly Thr Ser Pro Arg Thr 
225 230 235 ■ 240 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210? 318 
<211> 251 
<212> PRT 

<213> Homo sapiens 



<400> 318 

Gin Val Gin Leu He Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 
50 55 60 ■ 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 160 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro, Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin .Gin Tyr Ala Thr Ser Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 319 
<211> 251 
<212> PRT 

<213> Homo sapiens 
<220> 

<221> Site 
<222> (115) 

<223> Xaa equals any of the naturally occurring L-araino acids' 



wo 02/02641 



PCT/USOl/19110 



<400> 319 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly He Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp He Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



He Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Gly Phe Gin Tyr Phe 
100 105 110 



Asp His Xaa Cys Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr Leu Thr Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 ' 155 150 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Ser Pro Arg Thr 



379 



wo 02/02641 



PCT/USOl/19110 



Phe Gly Gin Gly Thr Arg Leu Glu lie Lys Arg 
245 250 



<210> 320 
<211> 251 
<212> PRT 
<213> Homo sapiens 



<400> 320 

Gin Val Gin Leu Val Gin Ser Gly Val Glu Val Lys Lys Pro Gly Ala 



Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn His 



Gly lie Ser Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Trp lie Ser Gly His Asp Asp Ser Thr Lys Tyr Ala Gin Lys Phe 



Gin Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 



lie Glu Leu Arg Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Pro Phe Tyr Asp Thr Leu Thr Ser Tyr Val Phe Gin Tyr Phe 
100 105 110 



Asp His Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly 
115 120 125 



Gly Ser Gly Gly Gly Gly' Ser Gly Gly Gly Gly Ser Ala Leu Glu Thr 
130 135 140 



Thr. Leu Thr. Gin Ser Pro Asp Thr Leu Ser Leu Ser Pro Gly Glu Arg 
145 150 155 ISO 



Ala Thr Leu Ser Cys Arg Ala Ser Gin Ser, Val Thr Arg Gly Trp Val 
165 170 175 



Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu Met Tyr 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Gly Thr Ser Arg Arg Ala Thr Gly Val Pro Asp Arg Phe Ser Gly £ 
195 200 205 



Glu Ser Gly Thr Asp Phe Thr Leu Thr He Ser Arg Leu Glu Pro Glu 
210 215 220 



Asp Phe Ala Val Tyr Tyr Cys Gin Gin Tyr Ala Thr Leu Pro Arg Thr 
225 230 235 240 



Phe Gly Gin Gly Thr Arg Leu Glu He Lys Arg 
245 250 



<210> 321 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 321 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 . 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp He 



Gly Gly He He Pro Met Phe Gly Thr Ala Thr Tyr Ser Gin Asn Phe 
50 55 60 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Gly Leu Asp Ser 
100 105 , 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ,150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser His Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 322 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 322 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ser Phe Asp Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ■ 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
130 • 135 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Tyr Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 323 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 323 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asp 



Ala He Asn. Trp Val Arg. Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



Gly Gly He 'He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



wo 02/02641 



PCT/LSOl/19110 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Ala Pro Leu Tyr Pro 
100 105 110 



Trp Qly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210' 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 324 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 324 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 . 25 '30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Gly Leu Asp Val 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 ■ 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 I 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 



wo 02/02641 



PCT/USOl/19110 



<210> 325 

■<211> 249 

<212> PRT 

<213> Homo sapiens 

<400> 325 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Se: 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met' Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie ' Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu . Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ser Leu Asp Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 ■ 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 _ 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Ala Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala 61u Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 326 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 32S 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys -Pro Gly Ser 



Ser Val Trp Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe ■ 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 "^^ . - 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ser Phe Asp Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 ■ 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 . 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 ' 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
- 210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 327 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 327 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 . 3 0 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 
65 ■ 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
130 185 ' 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 328 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 32B 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Tyr Leu Leu Leu Phe Pro His His Ser Phe Asp Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 ■ 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Pro Leu Gly .Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp. Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 . 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 329 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 329 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys' Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



390 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn : 
50 55 60 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
S5 70 ' 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ser Phe Asp Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Thr Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 . 205 



Thr Ala Ser Leu. Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 330 



391 



wo 02/02641 



PCT/USOl/19110 



<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 330 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp , Leu Leu Leu Phe Pro His Asp His Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 , 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Asn Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 331 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 331 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly 'Thr Phe Asn Asn Asn 



, lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Asp Pro Leu Gly Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 . ■ 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



393 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Pro Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



<210> 332 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 332 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr His Pro Leu Ser Phe 
100 105 110 - 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 ■ 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser. Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 



<210> 333 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 333 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Ala Pro Leu Phe Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys- Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



<210> 334 

<211> 249 ' 

<212> PRT 

<213> Homo sapiens 

<400> 334 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



wo 02/02641 



PCT/USOl/19110 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Asp Pro Leu Ser Leu 
100 105 110 



Trp Ser Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu -Ala i 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser- Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 335 

<211> 249 

<212> PRT 

<213> Homo sapiens 



397 



wo 02/02641 



PCT/USOl/19110 



<400> 335 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ala Pro Leu Ser Phe 
100 ■ 105 • 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 12 0 12 5 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 ■ 135 140 



Thr Glh Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
■ 180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 336 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 336 

Gin Val Pro Leu Gin Arg Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg -Asp Leu Leu Leu Phe Pro Ala Ser Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 . 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Giu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 337 
<211> 248 
•;212> PRT 

<213> Homo sapiens 
<400> 337 

Gin Val- Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala. He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Asp Ala Leu Ser Trp 
100 105 110 



Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
115 120 125 



Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu Thr 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val Thr 
145 150 _ 155 160 



Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin Gin 
165 170 175 



Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn Arg 
180 135 190 



Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
195 200 205 



Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asn Tyr 
210 215 220 



Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly Gly 
225 230 235 240 



Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 338 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<4:00> 338 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp- Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg' Asp Leu Leu Leu Phe Pro Ser Ala- Pro Leu Arg Phe 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 12 0 12 5 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 ■ 140 



• Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 ^ 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



, <210> 339 
.<211> 248 
<212> PRT 

<213> Homo sapiens 
<400> 339 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Ser Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 ■ ' 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Asp Pro Leu Glu Trp 
100 105 110 



Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
115 120 125 



Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu Thr 
130 135 140 



Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val Thr 
145 150 155 160 



Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin Gin 
165 170 175 



Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn Arg 
IBO 185 190 



Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
195 200 205 



Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp Tyr 
210 215 220 



Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly Gly 
225 230 235 240 



Gly Thr Glu Leu Thr Val Leu Gly 
■ 245 



<210> 340 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 340 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Ser Pro Leu Tyr Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Tyr Ser Ser Gly Asn 
195 200 205' 



Thr Ala Ser Leu Thr He Ser Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Tyr Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
22-5 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



404 



wo 02/02641 



PCT/USOl/19110 



<210> 341 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 341 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Glri Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Gly Ser Arg Asp Leu Leu Leu Phe Pro His Ser Ser Leu Val Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ISO' 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val ,Ile Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200' 205 



405 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp- Ser Ser Gly Asn His Tarp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 342 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 342 

Gin Val Gin Leu Gin Gin Ser' Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



-Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Asp Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 12 0 . 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
13 0 13-5 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



406 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn 1 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



<210> 343 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 343 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Tyr Phe 
100 105 110 ■ 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr.Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 .170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
130 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<2i0> 344 • ■ , . 

<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 344 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly' Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 30 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Ser Pro 
100 105 110 



Trp Gly Arg Gly Thr Meh Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
IBO 185 • 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 345 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 345 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg- Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 



wo 02/02641 



PCT/USOl/19110 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Ser Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<2X0> 346 
<211> 249 



410 



wo 02/02641 



PCT/USOl/19110 



<212> PRT 

<213> Homo sapiens 

<400> 346 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Phe Pro Met Ala Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
lis 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 ' 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 . 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Tyr Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Asp 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 347 
<211> 248 
<212> PRT 

<213> Homo sapiens 
<400> 347 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Pro Leu Tyr Trp 
100 105 110 



Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
115 120 125 



Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu Thr 
130 135 140 



Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val Thr 
145 150 155 160 



Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin Gin 
165 170 175 



412 



wo 02/02641 



PCT/USOl/19110 



Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn Arg 
180 185 190 



Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
195 200 205 



Ala Ser neu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp Tyr 
210 215 220 



Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly Gly 
225 230 235 240 



Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 348 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 348 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Asp Pro Leu Ser Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 349 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 349 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Sly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Asp Pro Leu Leu Ser 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 . 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 350 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 350 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Gly Pro Leu Leu lie 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
13 0 13 5 14 0 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 351 
<211> 249 
<212> PRT 
<213> Homo sapiei 

<400> 351 



416 



wo 02/02641 



PCT/USOl/19110 



Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
15 10 15 

Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
55 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gly Ser Pro Leu Leu Phe 
100 105 110 • 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 , 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr ■ Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



He Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



417 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 352 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 352 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ala Ala Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly i 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



<210> 353 
<211> 249 
<212> PRT 

<:213> Homo sapiens 
<400> 353 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Ser Asn Asn Asn 
20 25 30 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu P,he Pro His Thr Pro Leu Arg Phe 
100 105 110 ■ 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 



419 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ser 
210 215 220 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 354 
<211> 248 
<212> PRT 

<213> Homo sapiens 
<400> 354 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Pro Leu Thr Trp 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
115 ' 120 125 



Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu Thr 
130 . 135. 140 



Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val Thr 
145 150 155 , ISO 



Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin Gin 
165 170 • 175 



Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn Arg 
180 185 190 



Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
195 200 205 



Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp Tyr 
210 215 220 



Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly Gly 
225 230 235 240 



Gly Thr Glu Leu Thr Val Leu Gly 

245 



<210> 355 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 355 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1 5 10- 15 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu 'Glu Trp Met 
35 40 ' 45 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Phe Ser Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 35S 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 355 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Se: 



wo 02/02641 PCT/USOl/19110 



Ser Val Arg Val.Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 SO 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser- Arg Asp Leu Leu' Leu Phe Pro Ser His Pro Leu Phe Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly -Lys Asn Asn 
180 185 • 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 '235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



wo 02/02641 



PCT/USOl/19110 



<210> 357 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 357 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
15 10 15 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
- 20 25 . 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 . 55 60 • 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Pro Leu Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala- Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



424 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 358 
<211> 249 
<212> PRT 
<213> Homo sapie: 



<400> 358 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asp 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Gin Tyr Leu Asp Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ' 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Xyr Gly Lys Asn Asn 
180 185 ■ 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 359 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 359 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Se: 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leii Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



426 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ISO 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 360 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 360 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 . 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Phe Pro Leu Val Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 351 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 361 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



428 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Meb 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 

55 70 75 80 

Met Glu Leu ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gly Ser Pro Leu Leu Asp 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 ■ 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Sin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 . 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr- Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala As] 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 362 
■;211> 249 
<212> PRT 



wo 02/02641 



PCT/USOl/19110 



<213> Homo sapiens 
<400> 362 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Ala Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ■ 150 155 ' 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Ser Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



430 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 363 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 363 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



Gin Gly Arg Val Ala- He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Tyr Leu Ser Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 3S4 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 364 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
15 10 15 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala. lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Thr Pro Leu Phe Pro 
100 105 ■ 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 .220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 365 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 365 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He .He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asp Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu. Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Pro Leu His Pro 
100 ' 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



<210> 366 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 366 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35- 40 '45 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu' Leu Leu Phe Pro His Ala Pro Leu Ala Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ser Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 . 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 - ' 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 367 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 367 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



435 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Thr Thr Leu Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 , 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 . 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 368 
<211> 249 
<212> PRT 

<:213> Homo sapiens 



<400> 368 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Ala Val Leu His Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Ala Val Ser Ser Gly Gly Gly Gly Ser 
lis 120 . 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
■ 130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He- Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
437 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly A.sn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 369 

<211> 249 

<212> PRT 

<213> Homo sapif 



<400> 369 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 

20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 

35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 

50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ser Pro Leu Arg Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



438 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 370 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 370 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Ala Ala Asp Glu Ser Thr Ser Thr Ala Ser 
S5 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Asp Ala Leu Ser Phe 
100 105 110 



439 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gi;^ Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 371 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 371 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Ala Pro Leu Asp Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser LeU' Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 



<210> 372 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 372 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



441 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Asp Pro Pro Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 ' 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



wo 02/02641 



PCT/USOl/19110 



<210> 373 
<211> 249 
<212> PRT 

•;213> Homo sapiens 
<400> 373 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Glu Pro Leu Trp Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 374 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 374 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Ser Asn 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 IBS 190 



Arg Pro Ser Gly He Pro Asn Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 

• 245 



<210> 375 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 375 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Leu Pro Leu Thr Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



445 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ' 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 ■ 205 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 375 
<211> 249 
<212> PRT 
<213> Homo sapii 



<400> 376 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pi-o Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



446 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ser Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 ■ 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 377 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 377 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Ser Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ser Pro Leu Gin Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 378 
<211> 249 
<212> PRT 
<213> Homo sapiens 



wo 02/02641 PCT/USOl/19110 



<400> 378 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
15 10 15 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 ' 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 SO 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Thr Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr -Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 . 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly Thr Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 



449 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 379 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 379 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Ala Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Th.r lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 , 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 380 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 380 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Pro Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Asp Pro Leu Tyr Phe 
100 105 • 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



451 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asp His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 381 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 381 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asi 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
35 90 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ala His Leu Leu Plie 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly, Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 3S2 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 382 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



453 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Gly Pro Leu Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phg Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly As] 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala. Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 383 
<211> 249 
<212> PRT 
<213> Homo sapiei 



<400> 383 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp His Ala Phe Phe Val 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr. Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 . 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 



455 



wo 02/02641 



PCT/USOl/19110 



<210> 384 
<211> 249 
<212> PRT 

<213i. Homo sapiens 
<4Q0> 384 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Asp Ser Gly Phe Ala 
100 105 110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Leu Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



456 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 385 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 385 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Tyr Leu Glu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 386 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 38S 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Ala Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro 'Arg Asp Pro Leu He He 
100 105 110 



458 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 . 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 387 

<211> 249 

<212> PRT 

<2,13> Homo sapiens 



<400> 387 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



459 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Ero Ser Ala Pro Leu His Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 383 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 388 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



460 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Ala Pro Leu Leu Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
■ 210 215 ' 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



:210> 389 



451 



wo 02/02641 



PCT/USOl/19110 



<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 389 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 SO 

Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Ala Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asn 
210 215 220 



462 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn S,er Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 -240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
24 5 



<210> 390 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 390 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Se: 



Met Glu Leu Ser Ser Leu Arg Ser Glu. Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ala Pro Leu Asp Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 . 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
ISO 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 391 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 391 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser, 
65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Ala Val Leu Asp He 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
lis 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 392 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 392 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met 'Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



465 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Glu Pro Leu Phe Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150- 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 393 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 393 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin 'Gly Leu Glu Trp Met 



466 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 ■ 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Val Leu Trp Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Lys Leu Thr Val Leu Gly 
245 



<210> 394 
<211> 248 
<212> PRT 

<213 5' Homo sapiens 



wo 02/02641 



PCT/USOl/19110 



<400> 394 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Gin Trp 
100 105 110 



Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
115 120 125 



Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Gly Leu Thr 
130 135 140 



Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val Thr 
145 150 155 160 



Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin Gin 
165 170 175 



Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn Arg 
180 185 190 



Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
195 200 205 



Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp Tyr 
210 215 220 



Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly Gly 
225 230 235 240 



468 



wo 02/02641 



PCT/USOl/19110 



Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 395 
<211> 249 
<212> PRT 
<212> Homo sapiens 



<400> 395 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Ser Pro Leu Ala Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 . 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 . 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



459 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 39S 
<211> 249 
<212> PRT 
<213>Homo sapiens 

<400> 396 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu His Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 397 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 397 

Glu Val Asn Leu Arg Glu Ser Gly Gly Gly Val Val Gin Pro Gly Arg 



Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
20 25 30 

Gly Met His Trp Val Arg Gin Ala Pro Gly Lys Gly Leu' Glu Trp Val 
35 40 45 

Ala Val lie Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
50 55 60 

Lys Gly Arg Phe Thr lie Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65 70 75 80 

Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 

Ala Lys Asp Gly Tyr Tyr Asp lie Leu Thr Gly Tyr Ser Tyr Tyr oiy 



471 



wo 02/02641 



PCT/USOl/19110 



Met Asp Val Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly 
115 120 125 



Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg lie 
145 150 155 ' 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 . 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly 
225 230 235 240 



Gly Gly Thr Lys Leu Thr Val Leu Gly 
245 



<210> 398 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 398 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly. Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



472 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro- Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 399 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 399 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser He Leu His Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



474 



wo 02/02641 



PCT/USOl/19110 



<210> 400 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 400 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Ser His 
100 105 110 



Trp Gly Arg Arg Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



475 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210? 401 
<211> 249 
<212> PRT 
<213> Homo sapif 



<400> 401 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Ala Ala Leu Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Axg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu lie lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



-Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 402 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 402 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala. Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser His Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 



477 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 ■ 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn 1 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 ■ 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 403 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 403 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala S^r 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ala Pro Leu Ser Ser 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 404 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400>.404 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Se: 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn PTae 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Thr Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phfe Ser Ser Glu Leu 
130 135 ■ 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ' 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185- , 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu -Gly 
245 



480 



wo 02/02641 PCT/USOl/19110 

<212> PRT 

<213> Homo sapiens 
<400> 405 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
15 10 15 

Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser. Gin- Asn Phe 
50 55 60 

Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
55 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 

Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Asp Pro Leu His Ser 
100 105 ■ 110 

Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
■ 115 120 125 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
■130 135 140 

Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ' 150 155 160 

Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 

Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 ■ 185 . 190 

Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 406 
<211> 249- 
<212> PRT 

<213> Homo sapiens 
<400> 40S 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys. Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Val Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Phe Pro Leu His Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin- Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155- 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 • 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 407 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 407 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala His Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Arg Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 , 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 



483 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asp 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 408 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 408 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



484 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Phe Glu Pro Leu lie He 
100 105 110 



Trp Gly Arg Gly Tlir Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115, 12 0 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 " 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ,160 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp. 
210 215 220 



Tyr Tyr Cys Asn Ser Arg, Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 409 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 409 

Gin Val Gin Leu Glh Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



485 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Ser Pro Leu Asn Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 . 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 1B5 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 410 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 410 



wo 02/02641 



PCT/USOl/19110 



Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Tyr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser- Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser , Ser Gly Asn His Trp Val Phe Gly 
225- 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 411 

<211> 249 

<212> PRT 

<213> Homo sapie: 



<400> 411 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ser Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 412 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 412 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Asp Gly Leu Ser Se: 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
13 0 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 



489 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 413 
<211> 249 
<212> PRT 
<213> Homo sapie] 



<400> 413 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He .Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro He Ser Pro Leu Cys Phe 
100 105 110 



490 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 . 235 240 



<210> 414 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 414 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ala Pro Leu Tyr Gly 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ■ 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Glri Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 415 

<211> 249 ' 

<212> PRT 

<213> Homo sapiens 

<400> 415 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ser Leu Phe Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



wo 02/02641 



PCT/USOl/19110 



<210> 416 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 416 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Gly Pro Leu Arg Phe 
100 105 110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 417 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 417 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Ala Pro Leu Ala Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 



495 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 ■ 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 • 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 418 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<40Q> 418 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Val Lys Tyr Ser- Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Leu Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



496 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 

245 



<210> 419 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 419 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 BO 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Phe Pro Leu lie Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Lei 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 , 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 420 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 420 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Glii Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Asp Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 'Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Pro Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr. Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 421 
<211> 249 
<212> PRT 



499 



wo 02/02641 



PCT/USOl/19110 



<213> Homo sapiens 
<400> 421 

Arg Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Asp Ser Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



500 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser.Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<21G> 422 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 422 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Se: 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ala Pro Leu Thr Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp- 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 423 

<211> 249 

<212> PRT 

<213> Homo sapii 



<40Q> 423 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val. Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Wet Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
S5 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Tyr Leu Leu Leu Phe Pro Tyr Ala Pro Leu Tyr Asp 
100 105 110 



Trp Gly -Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



502 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 , 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Lys 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 .240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 424 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 424 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



503 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 425 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 425 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ala Pro Leu Asp Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
13 0 135 14 0 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val Thr Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 426 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 426 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



505 



wo 02/02641 



PCT/USOl/19110 



Ser Ala Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Thr His Leu Thr Phe 
100 105 - 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser' Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 427 
<211> 249' 
<212> PRT 

<213> Homo sapiens 



<400> 427 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Ser Leu Asp Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 



507 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Ttir He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
■ 245 



<210> 428 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 428 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 

50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 

65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn His Pro Met Phe Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 , 155 160 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser- Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala . 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 429 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 429 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met. 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Ser Ser Leu Glu Phe 
100 105 110 



509 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Leu Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Val Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 430 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 430 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Ala Pro Leu His Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 431 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 431 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



511 



wo 02/02641 



PCT/USOl/19110 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ala His Leu Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser' Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



wo 02/02641 



PCT/USOl/19110 



<210> 432 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 432 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Tlir Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Asp Pro Leu His Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly -Gin Thr Val Arg Val 
145 ■ 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
513 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 433 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 433 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Asp Ala Leu Gin Ser 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
13 0 13 5 14 0 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



514 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 434 
<211> 249 
<212> PRT 
<213> Homo sapii 



<400> 434 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Thr Pro Leu Thr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 ' 125 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 435 
<211> 249 
<212> PRT 
<213> Homo sapii 



<400> 435 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala 



516 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Ala His Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Sei 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 436 
<211> 249 
<212> PRT 
<213> Homo sapii 



<400> 43S 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
517 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ala Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Arg Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 437 

<211> 249 

<212> PRT 

<213> Homo sapiens 



518 



wo 02/02641 



PCT/USOl/19110 



<400> 437 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Phe Ser Pro Leu Ala Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 , 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 



519 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 438 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 438 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ala Pro Leu Asp Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val Thr Tyr Gly Lys Asn Asn 
180 135 190 



520 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 439 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 439 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ala Pro Leu Arg Phe . 
100 105 • 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



521 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala 1 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 440 
'<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 440 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met. Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



522 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Arg He 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly -Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 • 235 240 



Gly Gly Thr Glu Leu Asn Val Leu Gly 
245 



<210> 441 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 441 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



523 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Glu Pro Leu Gin Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly Thr Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 442 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 442 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



524 



wo 02/02641 



PCT/USOl/19110 



er Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser, 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Asp Pro Leu Ser Ala 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Se: 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 



525 



wo 02/02641 



PCT/USOl/19110 



<210> 443 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 443 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Asn Pro Pro He Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 12,0 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ' 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



526 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 444 
<211> 249 
<212> PRT 
<:213> Homo saple: 



<400> 444 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Wet Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Thr Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 445 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 445 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Asp Leu 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225' 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 446 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 446 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin, Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
529 



wo 02/02641 PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Phe Asp Pro Leu Leu lie 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 . 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 . 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 447 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 447 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



530 



wo 02/02641 



PCT/USOl/19110 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Asp Ala Leu Arg He 
100 105 110 • 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser His Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



531 



wo 02/02641 



PCT/USOl/19110 



<211> 249 
<212> PRT 

<:213> Homo sapiens 
■;400> 448 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Ala Pro Leu Thr Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 

195 ■ ■ 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly GLy Th.r Glu Leu Thr Val Leu Gly 
245 



<210> 449 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 449 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asi 
20 25 30 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 

35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 

50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 

65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Glu Gly Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 450 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 450 

Gin Val Gin Leu Gin Gin Pro Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Ala Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Sar Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 451 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 451 

His Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Girl Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Se: 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr' Tyr Cys 



535 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Asp Ser Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asn Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr I-le Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 452 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 452 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Ser Pro Leu' Thr His 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn , 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 ^ 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 453 > 
<211> 248 
<212> PRT 

<213> Homo sapiens 



wo 02/02641 



PCT/USOl/19110 



<400> 453 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Asp Pro Leu He Trp 
100 105 110 



Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
115 120 125 



Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu Thr 
130 135 140 



Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val Thr 
145 150 155 160 



Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin Gin 
165 170 175 



Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn Arg 
180 185 190 



Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
195 . 200 205 



Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp Tyr 
210 215 220 



Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 454 
<211> 249 
<212> PRT, 
<213> Homo sapiens 



<400> 454 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Thr Pro Leu Leu He 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 455 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 455 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Thr Pro Leu His Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



540 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ISO 155 160 

Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 

Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 

Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 

Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 

Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 456 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 45S 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 SO 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
35 90 95 

Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Asp Ala Leu Tyr Phe 
541 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Arg Pro Gly Gin Ala Pro Val Leu Val lie. Tyr Gly Lys Asn Asn 
180 " 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 457 
<211> 249 
<212> PRT 

.<213> Homo sapiens 
<400> 457 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Thr Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 458 
<211? 249 
<212> PRT 

<213> Homo sapiens 
<400> 458 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser 'Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Gin Pro Leu Thr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Se: 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



wo 02/02641 



PCT/USOl/19110 



<210> 459 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 459 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He lie Pro Met Phe Gly Thr Ala Lys Tyr' Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Thr Tyr Leu Asp Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 ' 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 • 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



545 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 460 
<211> 249 
<212> PRT 
<213> Homo saplei 



<400> 4S0 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Pro Leu His Ser 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Ser His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 461 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 461 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His His Ser Phe Asp Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ■ 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser' Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 462 
<211> 249 
<212> PRT 
<213> Horao sapiens 



<400> 462 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asp 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 ■ 75 80 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ser Pro Leu Gin Pro 
100 105 110 



Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala i 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 463 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 463 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr His Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu 'Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 

245. 



<210> 464 
<211> 249 



wo 02/02641 



PCT/USOl/19110 



<212> PRT 

<213> Homo sapiens 
<400> 464 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu He Phe 
100 105 110 



Trp Gly Trp Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 135 , 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



551 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Th.r Val Leu Gly 
245 



<210> 465 

<211> 249 

<212> PRT , 

<213> Homo sapiens 

<400> 455 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Met Ala Pro Leu Ser Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
130 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 466 
<211> 249 
<212> PRT 
<213> Homo sapii 



<400> 466 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Ser Gly Leu Asp i 
100 105 110- 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 467 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 467 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Ala Pro Leu Ser Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He' Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 • 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 458 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 4S8 

Gin Val Gin Leu Gin Gin Pro Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Lys Ser Pro He Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Set Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 ■ 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 4 69 
<211> 249 
<212> PRT 
<213> Homo sapie] 

<400> 469 



556 



wo 02/02641 



PCT/USOl/19110 



Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Se; 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ser Pro Leu Phe Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 . 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin ' 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 • 



<210> 470 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 470 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Phe 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Ser Pro Leu Phe Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 12 0 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 1B5 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 . 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 . 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 471 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 471 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glii Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Tyr Gly Met Asp Val 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Arg Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie' Thr Gly Ala. Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 472 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 472 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



■Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ser Pro Leu Leu Phe 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



Trp Ser Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 473 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 473 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly His Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



561 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr His Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Val Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
24 5 



<210> 474 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 474 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cy-s Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Val lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Ala Leu Arg Phe 
100 ■ 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 ' 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



wo 02/02641 



PCT/USOl/19110 



<210> 475 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 475 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Ket Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Pro Tyr Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 476 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 476 

Gin Val Gin Leu Gin .Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr. Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Ala Pro Leu Phe Asp 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 



565 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 

Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 477 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 477 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 

Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 ■ 45' 

Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 

Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Phe Thr Phe 
100 X05 110 

Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 478 

<211> 249 

<212> PRT 

<213> Homo sapie: 



<400> 478 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala 'Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 30 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Val Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 , 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
ISO 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 479 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 479 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 



wo 02/02641 



PCT/USOl/19110 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Tyr Gly Met Asp Val 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Arg Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 480 
<211> 249 
<212> PRT 



569 



wo 02/02641 



PCT/USOl/19110 



<213> Homo sapiens 
<400> 480 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Tyr Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Arg Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Ser His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 481 
<211> 249. 
<212> PRT 
<213> Homo sapiens 

<400> 481 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly 'Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Ser Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 • 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 



571 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Tlir Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 482 
<211> 249 
<;212> PRT 

<213> Homo sapiens 
<400> 482 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Phe Thr 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 • 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 4B3 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 483 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Asp Pro Leu Leu lie 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 ' 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr^ Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 ■ 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 484 

<211> 248 

<212> PRT 

<213> Homo sapiens 



<400> 484 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



574 



wo 02/02641 



PCT/USOl/19110 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Gin Trp 
100 105 110 



Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
115 120 125 



Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val Thr 
145 150 155 160 



Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin Gin 
165 170 175 



Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn Arg 
180 185 190 



Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr 
195 200 205 



Ala- Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp Tyr 
210 215 220 



Tyr Cys Asn Ser Arg Asp Ser Ser Gly Ser His Trp Val Phe Gly Gly 
225 230 235 240 



Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 485 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 485 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Th.r Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser His Ala Phe His Glu 
100 105 110 



Trp Asp Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135' 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 4B6 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 436 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn His Pro Leu Tyr Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 . 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190. 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser. Gly Ser Ser Ser Gly Asn 



577 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220- 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 . 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 487 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 487 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala. He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Wet Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Ser Pro Leu Phe Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Tlir Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



578 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 488 
<211> 249 
<212> PRT 
■ <213> Homo sapi« 



<400> 488 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Arg Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Asp Pro Leu His Pro 
100 105 110 ■ , 



579 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 • 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 489 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 489 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 SO 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala i 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Ala Pro Leu Phe Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 , 120 125 



Gly Gly Gly Gly Ser Sly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser. Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 490 
<211> 249 , 
<:212> PRT 

<213> Homo sapiens 
<400> 490 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



581 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Pro Leu Leu He 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 " 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 

245 



wo 02/02641 



PCT/USOl/19110 



<210> 491 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 491 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gly Ser Pro Leu Leu Phe 
100 105 110 



Trp Ser Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 492 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 492 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys ' Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Thr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 ' 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Pro Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 ■ 175 



584 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thrlle Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 493 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 493 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Gin Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



585 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp. Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Leu Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 . 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
.225 230 235 240 



Gly Gly Thr Glu Leu. Thr Val Leu Gly 
245 



<210> 494 
<211> 249 
<212> PRT 
<.213> Homo sap if 



<4O0> 494 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 80 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr ' Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Ser Pro Leu Trp Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 ■ 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu' Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn • 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210>,495 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> .495 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe- Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
587 



wo 02/02641 



PCT/USOl/19110 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Phe Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
" 130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly ' 
245 



<210> 496 
<211> 249 
<212> PRT 

<213> Homo sapiens 



wo 02/02641 



PCT/USOl/19110 



<400> 496 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Mfet 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Gly Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Asp Pro Leu Leu Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He. Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 



589 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 497 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 497 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Ser Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 _ 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 1S5 190 



590 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 498 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 498 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ser Pro Leu Arg He 
100 105 • 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val' Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu. Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 

245 



<210> 499 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 499 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 • 95 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ala Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
IBO 185 . 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 500 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 500 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
593 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Thr Pro Leu Thr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 501 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 501 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



594 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Sei 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Ala Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 



595 



wo 02/02641 



PCT/USOl/19110 



<210> 502 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 502 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Gin Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg. Pro- Ser Gly lie Pro Asp Arg Phe Ser Gly. Ser Ser Ser Gly Asn 
195 200 205 



595 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 503 
<211> 249 
<212> PRT 
<213> Homo sapie] 



<400> 503 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Leu Glu Pro Met His Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ISO 155 160 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Gly Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 . 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 504 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 504 

Gin Val Gin Leu Gin Gin Seir Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



.la He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ala Pro Leu Thr Phe 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



Trp Ser Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp' Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 505 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 505 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala .lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



599 



wo 02/02641 



PCT/USOl/19110 



65 70 75 80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser His Pro Leu Leu Phe 
100 105 110 

Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu 'Gly Gin Thr Val Arg Val 
,145 150 155 160 

Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 

Gin Lys' Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 . 205 

Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 

Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 506 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 506 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1 5 - 10 15 

Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



wo 02/02641 



PCT/USOl/19110 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Val He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Thr Pro Leu Val Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 , 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 IBS 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Ser Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



:210> 507 



601 



wo 02/02641 



PCT/USOl/19110 



<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 507 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Ala Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 '40 45 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
65 70 75 30 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 95 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gly Ser Pro Leu Thr Phe 
100 105 , 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



602 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 508 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 508 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ala Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 509 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 509 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



' Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala 'Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ala Pro Leu Asp Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130, 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 510 
<211> 249 
<212> PRT 
<213> Homo sapii 



<400> 510 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro. Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



605 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser His Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 511 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400i 511 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



606 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Phe Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
lis 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly- Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 ■ 185 . 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala i 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 512 
<211> 249 
<212> PRT 

<213> Homo sapiens 



wo 02/02641 



PCT/USOl/19110 



<400> 512 

Gin Val Gin Leu Val Glu Ser Gly Gly Gly Val Val Gin Pro Gly Arg 



Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 



Gly Met His Trp Val Arg Gin Ala Pro Gly Lys Gly Leu Glu Trp Val 



Ala Ala lie Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 



Lys Gly Arg Phe Thr He Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 



Leu Gin Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Lys Asp Gly Tyr Tyr Asp He Leu Thr Gly Tyr Ser Tyr Tyr Gly 
100 105 110 



Met Asp Val Trp Gly Gin Gly Thr Met Val Thr Val Ser Ser Gly Gly 
115 120 125 



Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg He 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Thr Asn Trp Phe Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Leu Leu Val Val Tyr Ala Lys Asn Lys 
180 ■ 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Lys Leu Thr Val Leu Gly 
245 



<210> 513 

<211> 249 

<212> PRT 

<213> Homo sapi( 



<400? 513 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Lys Pro Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 • 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Glh Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 21S ■ 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 514 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 514 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly. Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu S,er Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asn Ser Thr Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe , Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 515 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 515 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp Ala Pro Leu Thr Pro 
611 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly. Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys ASn Ash 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 , 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala ; 
210 ■ 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 516 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 516 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Glu Pro Leu Leu He 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 ' 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 517 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 517 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Tyr Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
lis 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys' Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



,Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



wo 02/02641 



PCT/USOl/19110 



<210> 518 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 518 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asp Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp ' Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Glu Pro Leu Val Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ssr Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 519 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 519 

Gin- Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro .Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Tyr Pro Leu His Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155' 160 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 520 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 520 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser , 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Asp Pro Leu Thr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
617 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 . 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 521 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<4G0> 521 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 
55 70 75 - 80 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Ala Pro Leu Thr Asn 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 522 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 522 

Glri Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



619 



wo 02/02641 



PCT/USOl/19110 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Glu Ala 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 no 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 523 
<211> 249 



wo 02/02641 



PCT/USOl/19110 



<212> PRT 

<213> Homo sapiens 

<400> 523 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Asp His Pro Leu Leu Phe 
100 ■ 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr' Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 • 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu- Gly 
245 



<210> 524 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 524 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ala Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Ser Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



S22 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220. 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 ■ 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 525 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 525 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp -Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg- Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Gly Pro Leu Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
623 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 • 215 ■ 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 526 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 526. 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
85 90 . 95 ■ 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Phe Thr Pro Leu Thr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 ■ 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 , 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyf Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 527 
<211> 249 
<212> PRT 
<213> Homo sapiens 



<400> 527 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 
35 40 45 



wo 02/02641 



PCT/USOl/19110 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin His Pro Leu Ser Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 ' 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 528 
<211> 249 
<212> PRT 
<213> Homo sapi( 



<400> 528 



wo 02/02641 



PCT/USOl/19110 



Gin Val 61n Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Gin Lys Pro Gly Gin 'Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 529 
<211> 249 
<212> PRT 
<213> Homo sapie 



<400> 529 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gin Ala Pro Leu Thr Phe 
100 105 110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 ' 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 



<210> 530 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 530 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ala Pro Leu Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin- Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 



629 



wo 02/02641 



PCT/USOl/19110 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
X80 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 • 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 531 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 531 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Se: 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Thr Pro Leu Thr Phe 
100 105 110 



wo 02/02641 



PCT/USOl/19110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser His Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225. 230 , 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 532 

<211? 249 

<212> PRT 

<213> Homo sapiens 



<400> 532 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp He 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 
50 55 60 , 



wo 02/02641 



PCT/USOl/19110 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Asp Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser "Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Ala Phe Gly 
225 230 235 240 



Gly Gly Thr Gly Leu Thr Val Leu Gly 
245 



<210> 533 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 533 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Gin Trp Met 



Gly Gly lie He Pro Wet Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Gly Phe Asp Ser 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 _ 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 

245 



wo 02/02641 



PCT/USOl/19110 



<210> 534 
<211> 249 
<212> PRT 
<213> Homo sapiens 

<400> 534 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu- Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Sej 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Tyr Ser Pro Leu Ser j 
100 105 110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 150 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly -He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



wo 02/02641 



PCT/USOl/19110 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 . 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 535 

<211> 249 

<212> PRT 

<213> Homo sapiens 



<400> 535 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val. Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Val 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Gly Arg Pro Leu Thr Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 



535 



wo 02/02641 



PCT/USOl/19110 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn- 
180 . 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg ASp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 53S 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 535 

Gin Val Gin Leu Gin Gin Ser Gly Ala' Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ala Glu His Leu Leu Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



635 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 " 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 135 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr lie Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 537 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 537 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



637 



wo 02/02641 



PCT/USOl/19110 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ala Pro Leu His Pro 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
155 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 533 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 538 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 
20 25 30 



wo 02/02641 



PCT/USOl/19110 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie He Pro Met Phe Gly Tiir Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Glu Pro Leu Thr Ala 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
1S5 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 539 
<211> 249 
<212> PRT 



639 



wo 02/02641 



PCT/USOl/19110 



<213> Homo sapiens 
<400> 539 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Sei 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Wet Phe Gly. Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Phe Glu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 ISO 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185' 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala 
210 215 220 



640 



wo 02/02641 



PCT/USOl/19110 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 540 
<211> 249 
<212>'PRT 

<213> Homo sapiens 
<400> 540 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn. Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Ala Pro Leu Asp Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 ■ 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 - 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val Thr Tyr Gly Lys Asn Asn 
641 



wo 02/02641 



PCT/USOl/19110 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Thr His Trp Val Phe Ala 
225 230 235 240 



Glu Gly Thr Lys Leu Thr Val Leu Gly 
245 



<210> 541 
<211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 541 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin. Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



. Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Phe Gly Thr' Leu Arg Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



wo 02/02641 



PCT/USOl/19110 



Thr Gin Asp Pro Ala Val Ser- Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr -Tyr Ala Ser Trp Tyr Gin 
165 . 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Arg Asn Asn 
18Q 135 19Q 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu'Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly- 
225 230 235' 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 542 
<:211> 249 
<212> PRT 

<213> Homo sapiens 
<400> 542 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly He He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn: Ser 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



wo 02/02641 



PCT/USOl/19110 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Ser Ser Pro Leu Val Phe 
100 ■ 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly' Gly Gly Gly Ser Ala Phe Ser Ser Glu'Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 - 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Ash Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 , 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 543 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 543 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala He Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



644 



wo 02/02641 



PCT/USOl/19110 



Gly Gly lie He Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala He Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Arg Asp Pro Leu Ala Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly He Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Trp Val Phe Gly 
225 230 235 240 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 544 
<211> 249 
<212> PRT 
<213>.Homo sapiens 



<400> 544 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



wo 02/02641 



PCT/USOl/19110 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro Thr Ser Pro Leu Ser Phe 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Pro Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 135 140 



Thr Gin Asp Pro Ala Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 . 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val He Tyr Gly Lys Asn Asn 
180 IBS 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 
195 200 205 



Thr Ala Ser Leu Thr He Thr Gly Ala Gin Ala Glu Asp Glu Ala Asp 
210 ■ 215 220 



Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Ser His Trp Val Phe Gly 
225 230 235 240 



wo 02/02641 



PCT/USOl/19110 



Gly Gly Thr Glu Leu Thr Val Leu Gly 
245 



<210> 545 
<211> 249 
<212> PRT 

<213> Homo sapiens 



<400> 545 

Gin Val Gin Leu Gin Gin Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 



Ser Val Arg Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Asn Asn 



Ala lie Asn Trp Val Arg Gin Ala Pro Gly Gin Gly Leu Glu Trp Met 



Gly Gly lie lie Pro Met Phe Gly Thr Ala Lys Tyr Ser Gin Asn Phe 



Gin Gly Arg Val Ala lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Ser 



Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 



Ala Arg Ser Arg Asp Leu Leu Leu Phe Pro His Ala Pro Leu Leu Leu 
100 105 110 



Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
115 120 125 



Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Ser Ser Glu Leu 
130 ■ 135 140 



Thr Gin Asp Pro Ala 'Val Ser Val Ala Leu Gly Gin Thr Val Arg Val 
145 150 155 160 



Thr Cys Gin Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gin 
165 170 175 



Gin Lys Pro Gly Gin Ala Pro Val Leu Val lie Tyr Gly Lys Asn Asn 
180 185 190 



Arg Pro Ser Gly lie Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn 



647
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